The other regions in the Midwest finishing with lower costs of doing business, starting at No. 1, were: Rapid City, Sioux Falls, Sioux City, Bismarck.
The three most expensive Upper Midwest cities for doing business were Minneapolis/St. Paul, Milwaukee and Wausau.
When looking at all of the 384 MSAs in the nation, Mankato ranked as the 64th lowest cost place to do business — putting it in the top 17 percent nationally for affordability.
The Mankato region was recently ranked as the 10th best on Fobes Best Small Metros for Business and Careers list, which included the 184 MSAs in the nation with populations of fewer than 250,000.