"I thought it was some of the better stuff he's had all year," manager Joe Girardi said. "I think he threw the ball exceptionally well except for a few mistakes."
About 13 hours after the Yankees finished a rain-delayed shutout Friday night, the teams were back on the field.
New York jumped on top in the first inning when Ichiro Suzuki doubled and scored on Robinson Cano's single. Deduno got Vernon Wells to ground into an inning-ending double play and settled in from there.
The right-hander, who pitched the Dominican Republic to the World Baseball Classic championship in March, received some help when Doumit caught Zoilo Almonte stealing second with a runner on third to end the fourth. Deduno struck out Suzuki with two on to finish the fifth and worked around a one-out double in the seventh.
"Everything was around the plate and everything was working today," Deduno said.
Plouffe tied it in the second on a long drive to left-center and Doumit put the Twins ahead in the seventh with a line drive to right.
"That's a single at Target Field. It might be an L-9," Doumit said, referring to Minnesota's pitcher-friendly home. "This is a great place to hit."
Gardenhire was tossed by plate umpire Vic Carapazza in the eighth after Clete Thomas and was called out for interference when Hughes' throw to first hit him in the back and bounced away. Aaron Hicks, who opened the inning with a bunt single, was sent back to first base.
Florimon followed with his fifth home run, a high fly that cleared the short porch in right to make it 4-1.
"It's frustrating," Hughes said. "I've felt good with my stuff over the last three or four starts. There's just one or two mistakes that I have to stay away from. I have a straight fastball, a four-seamer, that when I miss over the plate with it, it leads to fly balls. I just have to concentrate on location, and it comes down to execution."